The following are the World Cup qualifying fixtures in Africa for Matchday Six of the 2026 FIFA World Cup CAF qualifiers.

All times are listed in GMT:

Sunday, March 23, 2025
- Group D: Eswatini v Mauritius – 13:00
- Group F: Kenya v Gabon – 13:00

Monday, March 24, 2025
- Group A: Guinea-Bissau v Burkina Faso – 16:00
- Group H: Namibia v Equatorial Guinea – 13:00
- Group H: Liberia v Sao Tome e Principe – 16:00
- Group F: Ivory Coast v Gambia – 19:00
- Group A: Ethiopia v Djibouti – 21:00
- Group H: Tunisia v Malawi – 21:00
- Group I: Central African Republic v Mali – 16:00
- Group I: Madagascar v Ghana – 19:00

Tuesday, March 25, 2025
- Group C: Benin v South Africa – 16:00
- Group C: Nigeria v Zimbabwe – 16:00
- Group C: Rwanda v Lesotho – 16:00
- Group D: Angola v Cape Verde – 16:00
- Group G: Botswana v Somalia – 13:00
- Group G: Uganda v Guinea – 16:00
- Group A: Egypt v Sierra Leone – 19:00
- Group B: Sudan v South Sudan – 19:00
- Group D: Cameroon v Libya – 19:00
- Group F: Burundi v Seychelles – 19:00
- Group B: Mauritania v Democratic Republic of Congo – 21:00
- Group B: Senegal v Togo – 21:00
- Group G: Algeria v Mozambique – 21:00
- Group I: Comoros v Chad – 21:00
- Group E: Morocco v Tanzania – 21:30